CPE-DB: An Open Database of Chemical Penetration Enhancers

An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...

An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...

Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review: Chemical Penetration Enhancers

NSort/DB: An Intranuclear Compartment Protein Database

Distinct substructures within the nucleus are associated with a wide variety of important nuclear processes. Structures such as chromatin and nuclear pores have specific roles, while others such as Cajal bodies are more functionally varied. Understanding the roles of these membraneless intra-nuclear compartments requires extensive data sets covering nuclear and compartment-associated proteins. ...

QSAR Analyses of Skin Penetration Enhancers

QSAR models for four skin penetration enhancer data sets of 61, 44, 42, and 17 compounds were constructed using classic QSAR descriptors and 4D-fingerprints. Three data sets involved skin penetration enhancement of hydrocortisone and hydrocortisone acetate. The other data set involved skin penetration enhancement of fluorouracil. The measure of penetration enhancement is the ratio of the net pe...